Every bacterial or viral infection, that our body has experienced in our lifetime or is currently challenged with, leaves its mark on the immune system. Analyzing a patient’s immune response, accurately reproduced using a blood sample and Lophius' technologies, provides more reliable and more rapid insights into certain infections than conventional test formats. At Lophius, we have fully embraced this paradigm and have built our diagnostic approach around interrogating the immune system’s status and history.
T cells have an amazing capacity to proliferate and to adopt functional roles aimed at clearing a host of an infectious agent. Different cell populations of the immune system show a specific and detectable reaction following in vitro stimulation with a pathogen-derived antigen. Lophius' core competency relies on mimicking a natural infection very closely in a diagnostic environment and analyzing specific biomarkers that unveil the immune status to a given pathogen (e.g. bacteria or viruses).
Lophius' scientific approach benefits from a deep understanding of the immune system and how to accurately reproduce and analyze immune reactions in an in vitro diagnostic environment. At the same time, the company is seamlessly applying molecular diagnostic approaches such as quantitative reverse transcription PCR (RT-qPCR)-based analytics to answer key diagnostic questions. This balanced approach makes Lophius an ideal partner to develop truly novel diagnostic solutions.