Advantages of T-activated^® proteins

In contrast to peptides and unmodified proteins, T-activated^® proteins (formulated with Lophius patented T-activation^® buffer) are processed and presented via the exogenous (MHC-II) and endogenous (MHC-I; cross-presentation) pathways by functional antigen-presenting cells (APC), thus mimicking a natural infection.

In addition, T-activated^® proteins result in a more efficient and HLA antigen-independent stimulation of a broad spectrum of clinically-relevant subpopulations of antigen-reactive effector cells (CD4⁺ and CD8⁺ T cells, NK and NKT-like cells).

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Specifications of T-activated® proteins

• Recombinant T-activated^® proteins for effective in vitro stimulation of antigen-specific effector cells including CD4+ T cells, CD8+ T cells, NK cells and NKT-like cells
• Processed by APC via the exogenous and endogenous antigen-presentation pathways
• For epitope-loading on MHC-II as well as MHC-I molecules by cross-presentation
• Actively processed by APC leading to a physiological and comprehensive stimulation of antigen-specific effector cells

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Datasheet of T-activated^® IE-1

Datasheet of T-activated^® pp65

Datasheet of T-activated® EBNA3A

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