|Ordering and shipment information
|T-activated® proteins:||IE-1, pp65, BLZF-1, EBNA3A, ImmunoScan Cocktail
||500 µl per vial
||ELISpot, FACS, ELISA
||worldwide cooled shipping
||0800 / 567 4487 (toll-free)
||Approximately 1-3 days
|Note: prices do not include shipping and freight costs, charges, taxes or custom duties
Advantages of T-activated® proteins
In contrast to peptides and unmodified proteins, T-activated® proteins (formulated with Lophius patented T-activation® buffer) are processed and presented via the exogenous (MHC-II) and endogenous (MHC-I; cross-presentation) pathways by functional antigen-presenting cells (APC), thus mimicking a natural infection.
In addition, T-activated® proteins result in a more efficient and HLA antigen-independent stimulation of a broad spectrum of clinically-relevant subpopulations of antigen-reactive effector cells (CD4+ and CD8+ T cells, NK and NKT-like cells).
T-activated® ImmunoScan Cocktail
The T-activated® ImmunoScan Cocktail, which is also available in a ready-to-use ELISpot kit (T-Track® ImmunoScan), contains a mixture of antigens derived from different viruses and bacteria to stimulate a broad antigen-specific T cell response. Additionally, bystander mechanisms and specific components mediate the reactivation of innate immune cells. Thus, stimulation with this cocktail allows the monitoring of host response markers including specific recall responses in studies of immunosuppressive conditions, immune modulating therapies and recovery following transplantation.
Specifications of T-activated® proteins
- Recombinant T-activated® proteins for effective in vitro stimulation of antigen-specific effector cells including CD4+ T cells, CD8+ T cells, NK cells and NKT-like cells
- Processed by APC via the exogenous and endogenous antigen-presentation pathways
- For epitope-loading on MHC-II as well as MHC-I molecules by cross-presentation
- Actively processed by APC leading to a physiological and comprehensive stimulation of antigen-specific effector cells
Specifications of T-activated® ImmunoScan Cocktail
- Measures adaptive and innate immune response
- Broad stimulation of antigen-specific recall responses
- Almost unrestricted by donors' HLA background
- Usable for several individual immunoassay formats (ELISpot, ELISA, FACS)
- For research use only
Select a T-activated® protein
||12311001||500 µl||250,00 €|
||12311002||500 µl||250,00 €|
||12312001||500 µl||490,00 €|
||12312002||500 µl||250,00 €|
|T-activated® ImmunoScan Cocktail
||12380001||200 µl||500,00 €|
|T-activated® ImmunoScan Cocktail
||12380002||500 µl||1.150,00 €|
Delivery time: Approximately 1-3 working days
Not available in: No restrictions
Please note that the prices of our products do not include shipping and freight costs, charges, taxes or customs duties.
Get a quote Select the quantity first and add your item into the shopping card.
Lophius' patented T-activation® Technology platform
The T-Track® CMV ELISpot kit is based on the in vitro stimulation of mononuclear cells of the peripheral blood with two immunogenic CMV-specific proteins:
- T-activated® IE-1
- T-activated® pp65
In contrast to peptides and unmodified proteins, T-activated® proteins (formulated with Lophius patented T-activation® buffer) are processed and presented via both the exogenous (MHC-II) pathway and endogenous (MHC-I; cross-presentation) pathway by functional antigen-presenting cells (APC), thus mimicking a natural infection (Figure 1).
Therefore, T-activated® proteins allow a more efficient and HLA antigen-independent stimulation of a broad spectrum of clinically-relevant subpopulations of antigen-reactive effector cells (CD4+ and CD8+ T cells, NK and NKT-like cells), as outlined in Figure 2.